A Quick and Simple Polarographic Method for Aluminum Measurement in Recombinant Hepatitis B Vaccine

a quick and simple polarographic method for aluminum measurement in recombinant hepatitis b vaccine

abstract        background and objective: aluminum salts are among the most common useful additive compounds in preparation of human and animal vaccines. aluminum phosphate and aluminum hydroxide are two additives that show good immunoadjuvant effects with many antigens. aluminum-containing vaccines lead to a better and longer immune response compared to adjuvant-lacking vaccines. the chromogen...

a simple and rapid quantitative method for determination of aluminum in recombinant hepatitis b vaccine

Evaluation of Thimerosal Removal on Immunogenicity of Aluminum Salts Adjuvanted Recombinant Hepatitis B Vaccine

     Thimerosal, which is approximately 50% mercury by weight is a preservative widely used in vaccines since the 1930’s. It meets the requirements for a preservative as set forth by Pharmacopeia challenge test and has been shown to be effective against a broad spectrum of pathogens. In July 1999, the Public Health Service agencies and vaccine manufacturers agreed that thimerosal should be redu...

Comparison of the Adjuvanticity of Aluminum Salts and Their Combination in Hepatitis B Recombinant Protein Vaccine Assessed in Mice

Background: Several adjuvants have been evaluated for vaccine formulations but alu-minum salts will continue to be used for many years due to their safety, low cost and adjuvanticity with different antigens. Two commonly used aluminum adjuvants, alumi-num hydroxide and aluminum phosphate have different adjuvanticity properties. Com-mercial recombinant protein hepatitis B vaccines containing alu...

Evaluation of Thimerosal Removal on Immunogenicity of Aluminum Salts Adjuvanted Recombinant Hepatitis B Vaccine

     Thimerosal, which is approximately 50% mercury by weight is a preservative widely used in vaccines since the 1930’s. It meets the requirements for a preservative as set forth by Pharmacopeia challenge test and has been shown to be effective against a broad spectrum of pathogens. In July 1999, the Public Health Service agencies and vaccine manufacturers agreed that thimerosal should be redu...

Differential Immunogenicity of A Recombinant Hepatitis B Vaccine in Iranian Neonates: Influence of Ethnicity and Environmental Factors

Objective: To compare immunogenicity of a recombinant hepatitis B (HB) vaccine in two groups of neonates born in two cities of Iran with different geographic and ethnic backgrounds.   Materials and Methods: Ten micrograms of a recombinant HB vaccine was administered under field condition to Iranian healthy neonates at 0, 1.5 and 9 months intervals. The subjects consisted of two groups of 290 an...